.iso-one .bg-box{
    position: relative;
    overflow: hidden;
    z-index: 1;
    transition: all 600ms ease;
}
.iso-one .bg-box:before{
    content: ' ';
    display: inline-block;
    width: 250px;
    height: 250px;
    background: #82ab28;
    border-radius: 50%;
    position: absolute;
    top: -120px;
    right: -120px;
    opacity: 1;
    transform: scale(0);
    transition: all 600ms ease;
    z-index: -1;
}
.iso-one .bg-box:hover:before {
    transform: scale(5);
}
.iso-one .bg-box:hover{
    color: #fff;
}

.grid-title{
    display: flex;
    grid-gap: 0 15px;
    align-items: center;
    position: relative;
    margin-bottom: 20px;
}
.iso-two .grid-title img{
    position: absolute;
    width: 28px;
    bottom: 0;
    left: 40px;
}
.iso-two .dashed-box:hover .grid-title>span{
    background-color: #f3f3f3;
    color: #f2aa23;
}
.iso-two .grid-title>span:first-child{
    width: 50px;
    height: 50px;
    text-align: center;
    position: relative;
    border: 2px dotted #ddd;
    border-radius: 50%;
    font-size: 18px;
    font-weight: 600;
    background: #ec9e40;
    color: #fff;
    animation: border-transform 7s linear infinite alternate forwards;
    transition: all 0.5s;
    box-shadow: 0 0 10px #ddd;
    display: inline-flex;
    align-items: center;
    justify-content: center;
    margin-right:15px;
}
@keyframes border-transform {
    0% {
        border-top-left-radius: 20px;
        border-bottom-right-radius: 20px;
    }
    25% {
        border-top-right-radius: 15px;
        border-bottom-left-radius: 15px;
    }
    50% {
        border-bottom-right-radius: 25px;
        border-top-left-radius: 25px;
    }
    75% {
        border-top-left-radius: 20px;
        border-bottom-right-radius: 20px;
    }
    100% {
        border-top-left-radius: 15px;
        border-bottom-right-radius: 15px;
    }
}

.cdmo-one,.cdmo-p,.cdmo-h3 {
    position: relative;
    padding: 10px 0 0 40px;
    margin-bottom: 15px;
}

.cdmo-one:before,.cdmo-p:before,.cdmo-h3:before {
    content: '';
    display: inline-block;
    width: 2.5px;
    height: 100%;
    background: #ddd;
    position: absolute;
    left: 10px;
    top: 0;
}

.cdmo-one p,.cdmo-p p,.cdmo-h3 h3,.cdmo-h3 .small-title {
    position: relative;
}

.cdmo-one p:before,.cdmo-p p:before,.cdmo-h3 h3:before,.cdmo-h3 .small-title:before {
    content: '';
    display: inline-block;
    width: 14px;
    height: 14px;
    position: absolute;
    left: -36px;
    top: 6px;
    background: #edbd78;
    border-radius: 30px;
}
.iso-three .grid{
    --rate: 80px calc(100% - 100px);
    align-items: center;

}
.iso-three .grid>span{
    display: inline-flex;
    width: 80px;
    height: 80px;
    background: #fff;
    box-shadow: 4px 4px 10px 0 rgba(0, 0, 0, 0.15);
    align-items: center;
    justify-content: center;
    margin-bottom: 20px;
    border-radius: 50%;
    transition: all ease .3s
}

.iso-three .grid>span img{
    width: 50px;
}
.iso-three .grid:hover span{
    background: #ec9e40;
}
.iso-three .grid:hover img{
    filter: brightness(100) saturate(0);
}

.panel-box {
   margin: 40px 0 10px 0;
}

@media (min-width: 992px) {
    .panel-box {
         column-count: 2;
         grid-gap: 30px;
    }

    .panel-box .show-right {
        margin-bottom: 0;
        height: 200px;
        width: 200px;
        position: relative;
        overflow: hidden;
        border-radius: 10px;
    }

    .panel-box .show-right img {
        margin-bottom: 0;
        position: absolute;
        left: 50%;
        top: 50%;
        transform: translate(-50%,-50%);
        min-height: 100%;
        min-width: 100%;
        max-width: 120%;
        width: auto;
    }
}

.panel-box h4>a,.panel-box h3>a,.panel-box .small-title>a {
    font-weight: bold;
    color: #397cd8;
}

.panel-box h4.panel-title,.panel-box h3.panel-title,.panel-box .panel-title {
    margin: 0;
    font-weight: bold;
    font-size: 1.15rem;
}

.panel-box h4>a:hover,.panel-box h3>a:hover {
    color: #23527c;
}

.panel-box .panel-default > .panel-heading {
    cursor: pointer;
    border-radius: 0;
    background: none;
    padding: 20px 20px 20px 40px;
    position: relative;
    border: 1px solid #cfe2cb;
    border-bottom: 1px solid transparent;
}
.panel-box .panel-default > .panel-heading:before{
    content: "\f061";
    font-family: 'icomoon';
    display: inline-flex;
    align-items: center;
    justify-content: center;
    border-radius: 30px;
    background: #82ab28;
    width: 20px;
    height: 20px;
    font-size: 11px;
    position: absolute;
    left: 10px;
    font-weight: normal;
    color: #fff;
}
.panel-box .panel-default > .panel-heading.collapsed{
    border-bottom: 1px solid #cfe2cb;
}

.panel-box .panel {
    box-shadow: none;
    margin-bottom: 20px;
    background: none;
    break-inside: avoid;
}

.panel-group .panel-heading+.panel-collapse .panel-body {
    padding: 0 20px;
    border: 1px solid #cfe2cb;
    border-top: none;
}

.panel-box .panel.col-md-6 {
    border-bottom: none;
}

.panel-box .panel-body {
    line-height: 1.56em;
}

.panel-box .panel-heading.collapsed>.panel-title:after {
    content: "\f067";
    font-family: 'icomoon';
    color: #959b89;
}

.panel-box .panel-heading>.panel-title:after {
    content: "\f068";
    font-family: 'icomoon';
    color: #999;
    font-size: 13px;
    position: absolute;
    top: 20px;
    right: 15px;
}
.fade {
    opacity: 0;
    -webkit-transition: opacity .15s linear;
    transition: opacity .15s linear
}

.fade.in {
    opacity: 1
}

.collapse {
    display: none
}

.collapse.in {
    display: block
}

.collapsing {
    position: relative;
    height: 0;
    overflow: hidden;
    -webkit-transition: height .35s ease;
    transition: height .35s ease
}
.iso-four h3{
    margin-bottom: 15px;
}
.iso-four .bg-box{
    border: 1px solid #ddd;
    background: #fff;
    box-shadow:0 5px 10px #f1f1f1;
    position: relative;
    overflow: hidden;
    z-index: 1;
}
.iso-four .bg-box:after{
    content: '';
    display: inline-block;
    width: 120px;
    height: 120px;
    background: #f4f7fe;
    border-radius: 50%;
    position: absolute;
    top: -60px;
    right:-60px;
    transition: all ease .4s;
    z-index: -1;
}
.iso-four .bg-box:hover:after{
    transform: scale(2);
}

.cell-list{
    margin-bottom: 25px;
}
.cell-list a,.cell-list span{
    display: block;
    align-content: center;
    padding: 3px 10px;
    background: linear-gradient(to right, #edf6f7, #f9f9f9);
    transition: all ease .4s;
    min-height: 42px;
    line-height: 1.4em;
}
.cell-list a:hover{
    transform: scale(1.03);
    background: linear-gradient(to right, rgba(248, 227, 201, 0.9), rgba(229, 246, 228, 0.5));
    color: #5a683a;
}