CAS 2140271-21-0 Famotidine-[13C] - Isotope / BOC Sciences

General Information
Catalog: BLP-011576
CAS: 2140271-21-0
Molecular Formula: C7[13C]H15N7O2S3
Molecular Weight: 338.43

General Information

Catalog: BLP-011576

CAS: 2140271-21-0

Molecular Formula: C7[13C]H15N7O2S3

Molecular Weight: 338.43

Chemical Structure

Description	Famotidine-[13C] is the labelled analogue of Famotidine. Famotidine is a histamine H2 receptor antagonist that inhibits stomach acid production. It can be used for the treatment of peptic ulcer disease and gastroesophageal reflux disease.
Synonyms	Famotidine 13C; Pepcid AC-13C; Famodil-13C; Gastridin-13C; Pepcidine-13C; Pepdine-13C; Quamatel-13C; Gaster-13C; Pepdul-13C; Pepcid RPD-13C; 3-(2-Guanidinothiazol-4-ylmethylthio)-N1-sulfamoylpropionamide-13C; N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine-13C
IUPAC Name	3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoyl(1-13C)propanimidamide
Related CAS	76824-35-6 (unlabelled)
Canonical SMILES	C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
InChI	InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)/i6+1
InChI Key	XUFQPHANEAPEMJ-PTQBSOBMSA-N
Purity	95% by HPLC; 98% atom 13C
Solubility	Soluble in Water (Very Slightly), Glacial Acetic Acid (Freely), Anhydrous Ethanol (Very Slightly)
Storage	Store at 2-8°C

Famotidine-[13C], a specialized form of the histamine H2-receptor antagonist famotidine, plays a pivotal role in scientific research. Delve into the intricate applications of Famotidine-[13C]:

Pharmacokinetic Studies: In the realm of pharmacokinetics, Famotidine-[13C] emerges as an indispensable tool for unraveling the absorption, distribution, metabolism, and excretion of famotidine within the body. By harnessing this labeled compound, researchers can meticulously quantify and scrutinize the drug's pharmacokinetic dynamics. This data serves as a cornerstone for tailoring dosage regimens and deciphering intricate drug interactions.

Metabolic Pathway Elucidation: Embark on a journey of metabolic exploration with Famotidine-[13C], unveiling the intricate metabolic destiny of famotidine within biological systems. By tracing the distinctive [13C] label, scientists can unveil the metabolic pathways and intermediates involved in the drug’s biotransformation. This revelation aids in identifying potential metabolites that may sway drug efficacy and safety considerations.

Drug-Drug Interaction Studies: Delve into the realm of drug interactions with the aid of Famotidine-[13C], shedding light on the potential interplay between famotidine and other pharmaceutical agents. Through vigilant monitoring of the labeled compound, researchers can delineate how co-administered drugs influence famotidine’s pharmacokinetic profile. This investigation is pivotal for shaping sound and efficacious drug combination therapies.

Bioavailability Assessments: Witness the power of Famotidine-[13C] in assessing the bioavailability of diverse famotidine formulations, unlocking crucial insights into drug delivery systems. By assessing the [13C] label in biological samples, researchers can juxtapose the bioavailability of varied formulations or administration routes. This evaluation lays the groundwork for designing enhanced and patient-centric drug delivery modalities.