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Larotrectinib-[d7]

General Information
Catalog: BLP-004420
CAS: 2365076-71-5
Molecular Formula: C21H15D7F2N6O2
Molecular Weight: 435.48
Chemical Structure
Larotrectinib-[d7]
Description Larotrectinib-[d7] is the labelled analogue of Larotrectinib. Larotrectinib is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC.
Synonyms (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-2,2,3,4,4,5,5-d7-1-carboxamide; Larotrectinib d7; LOXO-101-d7; Larotrectinib D7; (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide-d7; LOXO 101-d7
IUPAC Name (4S)-2,2,3,3,4,5,5-heptadeuterio-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-4-hydroxypyrrolidine-1-carboxamide
Related CAS 1223403-58-4 (unlabelled)
Canonical SMILES [2H][C@@]1(C(C(N(C1([2H])[2H])C(=O)NC2=C3N=C(C=CN3N=C2)N4CCC[C@@H]4C5=C(C=CC(=C5)F)F)([2H])[2H])([2H])[2H])O
InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1/i5D2,8D2,12D2,14D
InChI Key NYNZQNWKBKUAII-PYTPNHQQSA-N
Purity >95%
Storage Store at 2-8 °C

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