CAS 2375621-21-7 Irbesartan-[d6] - Isotope / BOC Sciences

General Information
Catalog: BLP-006107
CAS: 2375621-21-7
Molecular Formula: C25H22D6N6O
Molecular Weight: 434.57

General Information

Catalog: BLP-006107

CAS: 2375621-21-7

Molecular Formula: C25H22D6N6O

Molecular Weight: 434.57

Chemical Structure

Description	Irbesartan-[d6] is an isotopically labelled analogue of Irbesartan, which is an angiotensin II type 1 (AII1)-receptor antagonist.
Synonyms	3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl-d2)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one; Irbesartan-d6; 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one-d6; Irbesartan-d6 (benzyl-d6)
IUPAC Name	2-butyl-3-[dideuterio-[2,3,5,6-tetradeuterio-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Related CAS	138402-11-6 (unlabelled)
Canonical SMILES	[2H]C1=C(C(=C(C(=C1C2=CC=CC=C2C3=NNN=N3)[2H])[2H])C([2H])([2H])N4C(=NC5(C4=O)CCCC5)CCCC)[2H]
InChI	InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)/i11D,12D,13D,14D,17D2
InChI Key	YOSHYTLCDANDAN-METDGUFKSA-N
Purity	98% by CP; 98% atom D
Solubility	Slightly soluble in DMSO, Methanol
Appearance	White to Off-White Solid
Storage	Store at-20°C

Irbesartan-[d6], a deuterium-labeled variant of the angiotensin II receptor antagonist Irbesartan, finds primary application in pharmaceutical research. Here are the key applications of Irbesartan-[d6]:

Pharmacokinetic Studies: Delving into the intricate realm of pharmacokinetics, Irbesartan-[d6] is a crucial tool for unraveling the absorption, distribution, metabolism, and excretion (ADME) of Irbesartan within the body. The deuterium labeling technique enables precise tracking and differentiation from the non-labeled drug, essential for optimizing dosing regimens and enhancing therapeutic efficacy.

Metabolite Identification: In the realm of drug development, Irbesartan-[d6] assumes significance as an internal standard for identifying and quantifying the metabolites of Irbesartan. Through the utilization of mass spectrometry, researchers can pinpoint the labeled compound and its metabolites with exceptional specificity. This aids in deciphering metabolic pathways and potential drug-drug interactions with a keen eye.

Improved Stability Studies: The deuterium labeling embodied in Irbesartan-[d6] bolsters its chemical stability, rendering it a valuable asset for exploring the drug's resilience under diverse conditions. Researchers can scrutinize degradation products and assess the compound’s shelf life with heightened precision. Such insights are indispensable for formulating stable pharmaceutical compositions tailored for optimal efficacy.

Therapeutic Drug Monitoring: Harnessing the potential of Irbesartan-[d6] in clinical environments, healthcare providers utilize this labeled variant to monitor the therapeutic levels of Irbesartan. By leveraging the labeled compound as a reference standard in assays, experts uphold the integrity of measurements ensuring accurate and reliable outcomes. This meticulous approach guarantees that patients receive precise dosages for effective management of blood pressure.