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10-Hydroxy Camptothecin-[d5]

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General Information
Catalog: BLP-001768
CAS: 1330277-66-1
Molecular Formula: C20H11D5N2O5
Molecular Weight: 369.38

Chemical Structure

Description	10-Hydroxy Camptothecin-[d5], is the labelled analogue of 10-Hydroxy Camptothecin. 10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM.
Synonyms	10-Hydroxy Camptothecin D5
IUPAC Name	(S)-4-(ethyl-d5)-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
Related CAS	19685-09-7 (unlabelled)
Canonical SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChI	InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1/i1D3,2D2
InChI Key	HAWSQZCWOQZXHI-CWDCNSFUSA-N
Melting Point	>216°C (dec.)
Purity	96% (CP); 98% atom D
Solubility	Soluble in DMSO, Methanol
Appearance	Dark Green Solid
Storage	Store at -20°C