2-Amino-2-deoxy-D-glucose-[1,2-13C2] hydrochloride

2-amino-2-deoxy-D-glucose-[1,2-13C2] hydrochloride, a specialized isotopic compound, holds immense potential in various advanced bioscience applications. Here are the key applications:

Metabolic Flux Analysis: Playing a crucial role in unraveling metabolic pathways, this glucose analog serves as a cornerstone in tracing carbon flux through glycolysis and the pentose phosphate pathway. By incorporating this compound into experiments, researchers can unveil profound insights into cellular metabolism and energy generation. It enables precise monitoring of metabolic intermediates and pathway dynamics across diverse physiological conditions.

Magnetic Resonance Spectroscopy (MRS): Applied in vivo to study brain glucose metabolism, 2-amino-2-deoxy-D-glucose-[1,2-13C2] hydrochloride facilitates detailed assessments of glucose turnover rates and utilization in neural tissues. This technique is particularly advantageous for investigating metabolic abnormalities in neurological disorders such as Alzheimer's disease and epilepsy, shedding light on the intricate metabolic processes within the brain.

Cancer Research: In the field of oncology, this compound serves as a vital tool in deciphering the altered glucose metabolism observed in tumor cells, often referred to as the Warburg effect. By introducing isotopically labeled glucose into cancer cell cultures, scientists can explore the metabolic shifts driving rapid cell proliferation. These investigations drive the advancement of targeted therapies that disrupt the metabolic pathways crucial for sustained tumor growth.

Glycoprotein Synthesis Studies: Furthermore, 2-amino-2-deoxy-D-glucose-[1,2-13C2] hydrochloride plays a significant role in research focused on glycoprotein biosynthesis. It aids in tracing the incorporation of glucose-derived carbon atoms into glycoproteins and complex carbohydrates. This application is essential for understanding diseases linked to glycosylation abnormalities and for propelling the field of glyco-engineered therapeutics forward.