Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-009162 |
Molecular Formula: C7H5D2NO3 |
Molecular Weight: 155.15 |
Chemical Structure |
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Description | 3-Hydroxyanthranilic acid-[4,6-d2] is the labelled analogue of 3-Hydroxy anthranilic acid. 3-Hydroxy anthranilic acid is an intermediate in the oxidative metabolism of tryptophan in the kynurenine pathway that demonstrates immunoprotective effects. |
Synonyms | 2-Amino-3-hydroxybenzoic acid-4,6-d2; 3-Oxyanthranilic acid-4,6-d2 |
Related CAS | 548-93-6 (unlabelled) |
Purity | 98% by HPLC; 98% atom D |
3-Hydroxyanthranilic acid-[4,6-d2], an isotopically labeled compound, finds primary utility in the realm of biochemical and metabolic exploration. Here are the key applications of 3-Hydroxyanthranilic acid-[4,6-d2] delivered with a high degree of perplexity and burstiness:
Metabolic Flux Analysis: Through tracer studies, researchers delve into cellular metabolic pathways using the labeled compound 3-Hydroxyanthranilic acid-[4,6-d2]. By incorporating this compound, researchers unravel its metabolic journey and decipher its processing under various physiological contexts. This elucidation aids in untangling metabolic irregularities and fine-tuning metabolic engineering strategies.
Biomarker Studies: Within clinical research, 3-Hydroxyanthranilic acid-[4,6-d2] assumes significance in identifying and quantifying biomarkers. Its isotopic labeling facilitates precise measurements through mass spectrometry, enabling a nuanced understanding of disease conditions and monitoring responses to therapeutic interventions.
Pharmacokinetics: In the domain of drug development, 3-Hydroxyanthranilic acid-[4,6-d2] serves as a pivotal tool for studying the pharmacokinetics of interacting or mimicking drugs. By scrutinizing its absorption, distribution, metabolism, and excretion (ADME) within the body, researchers glean insights into drug behavior, optimizing dosage regimens and enhancing the safety and efficacy profiles of novel therapeutics.
Enzyme Mechanism Studies: The isotopically labeled 3-Hydroxyanthranilic acid-[4,6-d2] offers a window into enzyme mechanisms linked to its interactions. By observing how the deuterium-labeled version impacts enzyme activity or binding affinity, researchers deepen their comprehension of enzyme dynamics and functionality. These revelations are instrumental in crafting enzyme inhibitors and therapeutic agents, pushing the boundaries of enzymology and drug development.
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