Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-007102 |
Molecular Formula: C5[13C]2H11[15N]O3 |
Molecular Weight: 160.15 |
Chemical Structure |
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Synonyms | 3-Methylcrotonylglycine (Glycine-13C2,15N) |
IUPAC Name | 2-(3-methylbut-2-enoyl(15N)amino)acetic acid |
Related CAS | 33008-07-0 (unlabelled) |
Canonical SMILES | CC(=CC(=O)NCC(=O)O)C |
InChI | InChI=1S/C7H11NO3/c1-5(2)3-6(9)8-4-7(10)11/h3H,4H2,1-2H3,(H,8,9)(H,10,11)/i4+1,7+1,8+1 |
InChI Key | PFWQSHXPNKRLIV-DPZTXFNWSA-N |
Purity | 98% by CP; 98% atom 13C; 98% atom 15N |
3-Methylcrotonylglycine-[Glycine-13C2,15N], a stable isotope-labeled compound utilized across diverse scientific research domains, is explored for its applications:
Metabolomics: Utilizing this labeled compound in metabolomics allows for tracing intricate metabolic pathways and measuring fluxes within biological samples. By scrutinizing the assimilation of stable isotopes into metabolites, researchers delve into the dynamic intricacies of metabolic processes, crucial for unraveling diseases linked to metabolic dysregulation and uncovering novel metabolic biomarkers of significance.
Proteomics: Within the realm of proteomics, integration of 3-Methylcrotonylglycine-[Glycine-13C2,15N] into proteins facilitates the study of protein synthesis, turnover, and degradation dynamics. This aids in monitoring the pulsating movement of proteins and comprehending the proteome's adaptive response to varied physiological or pathological stimuli. Such in-depth studies play a pivotal role in identifying potential therapeutic targets, shedding light on intricate protein functionalities, and exploring nuanced protein interactions.
Enzyme Activity Assays: This isotopically labeled compound serves as a valuable tool for probing into enzyme activities linked to glycine as a substrate or product. By employing 3-Methylcrotonylglycine-[Glycine-13C2,15N], researchers achieve meticulous measurements of enzyme kinetics and catalytic mechanisms, a critical facet in developing enzyme modulators like inhibitors or activators as promising therapeutic interventions.
Environmental Research: Delving into the environmental research domain, 3-Methylcrotonylglycine-[Glycine-13C2,15N] offers insights into the organic compounds' fate within ecosystems. Introducing the labeled compound into soil or water samples aids researchers in deciphering degradation and transformation paths, unveiling crucial data on the environmental repercussions of organic contaminants, and formulating strategies for eco-friendly bioremediation practices.
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