4-aminobutyric acid-[13C4]

4-Aminobutyric acid-[13C4], a stable isotope-labeled compound widely utilized in bioscience research, serves diverse functions. Here are the key applications of 4-aminobutyric acid-[13C4]:

Metabolic Pathway Research: Delving into the intricate metabolic pathways of GABA (gamma-aminobutyric acid), researchers employ 4-aminobutyric acid-[13C4] to meticulously trace and analyze its journey within biological systems. By integrating this labeled compound, scientists can meticulously track its metabolic destiny through cutting-edge mass spectrometry techniques. This method aids in unraveling the dynamic intricacies of GABA metabolism and sheds light on its pivotal role in various physiological processes.

Neuroscience: Within the realm of neuroscience, 4-aminobutyric acid-[13C4] emerges as a vital tool for probing the functionality of inhibitory neurotransmission. By strategically labeling GABAergic pathways, researchers delve into the synthesis, release, and recycling of GABA within neurons, unraveling the complexities of inhibitory signaling. This exploration plays a critical role in comprehending disorders linked to inhibitory signaling, such as epilepsy and anxiety, offering valuable insights for therapeutic advancements.

Stable Isotope Labeling Studies: Leveraging the power of stable isotope labeling, 4-aminobutyric acid-[13C4] facilitates in-depth investigations into metabolic changes within cells and tissues. Through targeted labeling of specific molecules, researchers conduct intricate analyses of metabolic fluxes using sophisticated techniques like NMR and MS. This methodological approach yields comprehensive insights into cellular metabolism and energy regulation under varying biological scenarios, opening new avenues for scientific exploration.

Drug Development: In the realm of pharmacology, 4-aminobutyric acid-[13C4] plays a pivotal role in advancing the development of drugs targeting GABAergic systems. By monitoring the distribution and metabolism of this labeled compound, pharmaceutical scientists evaluate the efficacy and pharmacokinetics of potential therapeutic agents with precision. This meticulous approach is fundamental in crafting drugs that modulate GABAergic signaling with enhanced specificity and efficacy, paving the way for innovative pharmaceutical interventions.