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Isotope Labeled Active Pharmaceutical Ingredients (APIs)
5-Azacytidine-[13C4]

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5-Azacytidine-[13C4]

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General Information
Catalog: BLP-003370
Molecular Formula: C4[13C]4H12N4O5
Molecular Weight: 248.18

Chemical Structure

Description	Labelled Azacytidine, produced by the strain of Streptoverticillium ladakanus var. ladakanus UC-2654. Azacitidine (Vidaza) is a chemotherapy drug used to treat conditions that affect the blood and the bone marrow, called myelodysplastic syndromes (MDS). It may also be used to treat other cancers, such as acute myeloid leukaemia (AML) or chronic myelomonocytic leukaemia (CMML). It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines). It can also act as a demethylating agent by inhibiting DNA methyltransferase.
Synonyms	Azacitidine-13C4; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one-13C4; 5-AC-13C4; 5-AZC-13C4; 5-AZCR-13C4; 5-AzaC-13C4; Antibiotic U 18496-13C4; Azacytidine-13C4; Ladakamycin-13C4
Related CAS	320-67-2 (unlabelled)