6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8]

General Information
Catalog: BLP-014103
Molecular Formula: C8H8D8N2O3
Molecular Weight: 196.27

General Information

Catalog: BLP-014103

Molecular Formula: C8H8D8N2O3

Molecular Weight: 196.27

Chemical Structure

Synonyms	N-Epsilon-acetyl-L-lysine-d8; H-Lys(Ac)-OH-d8; L-ε-N-Acetyllysine-d8; N6-Acetyllysine-d8; NSC 102777-d8; Nε-Acetyl-L-lysine-d8; Nε-Acetyllysine-d8; ε-Acetyl-L-lysine-d8; ε-N-Acetyl-L-lysine-d8; ε-N-Acetyllysine-d8; ω-N-Acetyl-L-lysine-d8; (S)-6-Acetamido-2-aminohexanoic acid-d8; N6-Acetyl-L-lysine-d8
IUPAC Name	(2S)-6-acetamido-2-amino-3,3,4,4,5,5,6,6-octadeuteriohexanoic acid
Related CAS	692-04-6 (unlabelled)
Canonical SMILES	CC(=O)NCCCCC(C(=O)O)N
InChI	InChI=1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1/i2D2,3D2,4D2,5D2
InChI Key	DTERQYGMUDWYAZ-IYVSXXDFSA-N
Melting Point	237-239°C
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in Methanol (Slightly), Water (Slightly)
Appearance	White to Off-white Solid
Storage	Store at -20°C under inert atmosphere

6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8] is a deuterated amino acid derivative with various applications in research and industry. Here are some key applications of 6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8]:

Protein Structure Analysis: 6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8] is utilized in NMR spectroscopy for detailed protein structure analysis. The deuterium labeling allows researchers to differentiate between hydrogen atoms and gain clearer insights into the protein’s conformation. This is essential for understanding protein folding, dynamics, and interactions.

Metabolic Flux Analysis: This deuterated compound can be used in metabolic flux analysis (MFA) to study amino acid incorporation and turnover in metabolic pathways. By tracing the labeled lysine through cellular processes, scientists can quantify metabolic rates and pathway activities. This is valuable for optimizing metabolic engineering and understanding cellular metabolism.

Epigenetic Modification Studies: 6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8] serves as a labeled substrate to investigate histone acetylation patterns in epigenetics research. The deuterium label allows for precise detection of modifications and their effects on gene expression. This helps unravel the complexities of epigenetic regulation and its implications in health and disease.

Pharmaceutical Development: In the pharmaceutical industry, this compound can be used to study drug interactions and stability. The deuterium atoms improve the detection of metabolites and degradation products in drug development studies. This aids in optimizing drug formulations and ensuring the efficacy and safety of new therapeutics.