| Description |
6(R)-[2-8(S)-2(S)-methylbutyryloxy)-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S))-ethyl]-4(R)-(dimethyl-tert-butylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one-[d3] is the labelled analogue of 6(R)-[2-8(S)-2(S)-methylbutyryloxy)-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S))-ethyl]-4(R)-(dimethyl-tert-butylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one, which is an intermediate in the synthesis of Lovastatin, an antihypercholesterolemic agent. |
| Synonyms |
Butanoic acid, 2-(methyl-d3)-, (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester, (2S)-; 6(R)-[2-8(S)-2(S)-methylbutyryloxy)-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S))-ethyl]-4(R)-(dimethyl-tert-butylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one-d3; 4(R)-(tert-butyldimethylsiloxy)-6(R)-[2-[1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutyryl]oxy]-1(S)-naphthyl]ethyl]-3,4,5,6-tetrahydro-2H-pyran-2-one-d3 |
| IUPAC Name |
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-(trideuteriomethyl)butanoate |
| Related CAS |
79691-11-5 (unlabelled)
|
| Canonical SMILES |
CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O[Si](C)(C)C(C)(C)C)C |
| InChI |
InChI=1S/C30H50O5Si/c1-10-20(3)29(32)34-26-16-19(2)15-22-12-11-21(4)25(28(22)26)14-13-23-17-24(18-27(31)33-23)35-36(8,9)30(5,6)7/h11-12,15,19-21,23-26,28H,10,13-14,16-18H2,1-9H3/t19-,20-,21-,23+,24+,25-,26-,28-/m0/s1/i3D3 |
| InChI Key |
YZUJIMXHROAZNZ-GLDHCNMCSA-N |
| Solubility |
Soluble in Chloroform, Dichloromethane, Ethyl Acetate |
| Appearance |
Foam |
![6(R)-[2-8(S)-2(S)-methylbutyryloxy)-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S))-ethyl]-4(R)-(dimethyl-tert-butylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one-[d3]](/isotope.v1/images/structure-default.jpg)
