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7-Ethyl-10-hydroxy camptothecin-[d4]

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General Information
Catalog: BLP-003125
CAS: 1309283-21-3
Molecular Formula: C22H16D4N2O5
Molecular Weight: 396.43

Chemical Structure

Description	7-Ethyl-10-hydroxy camptothecin-[d4] is a labelled form of 7-Ethyl-10-hydroxycamptothecin. SN-38 is the active metabolite of irinotecan. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be excreted from the body in its SN-38 form. SN-38 is lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan. 7-Ethyl-10-hydroxycamptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used in cosmetics material.
Synonyms	(S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione-5,10,12,12-d4
Related CAS	86639-52-3 (unlabelled)