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7-Ethyl-10-hydroxycamptothecin-[d5]

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General Information
Catalog: BLP-013006
CAS: 718612-51-2
Molecular Formula: C22H15D5N2O5
Molecular Weight: 397.45

Chemical Structure

Description	7-Ethyl-10-hydroxycamptothecin-[d5] is the labelled analogue of 7-Ethyl-10-hydroxycamptothecin, which is the active metabolite of irinotecan, a DNA topoisomerase inhibitor.
Synonyms	7-Ethyl-10-hydroxycamptothecin-d5 (SN 38-D5); 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-11-(ethyl-d5)-4,9-dihydroxy-, (4S)-; 10-Hydroxy-7-ethylcamptothecin-d5; SN 38 Lactone-d5; USP Irinotecan Related Compound B-d5
IUPAC Name	(19S)-19-ethyl-7,19-dihydroxy-10-(1,1,2,2,2-pentadeuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
Related CAS	86639-52-3 (unlabelled)
Isomeric SMILES	[2H]C([2H])([2H])C([2H])([2H])C1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O
Canonical SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)O
InChI	InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1/i1D3,3D2
InChI Key	FJHBVJOVLFPMQE-BOQQFKKFSA-N
Melting Point	227-233°C
Purity	>95%
Solubility	Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
Appearance	Light-Yellow Solid
Storage	Store at -20°C