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Afatinib-[13C6]

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Afatinib-[13C6]

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General Information
Catalog: BLP-003032
Molecular Formula: C18[13C]6H25ClFN5O3
Molecular Weight: 491.89

Chemical Structure

Description	Afatinib-[13C6] is the labelled analogue of Afatinib. Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Synonyms	[13C6]-Afatinib
IUPAC Name	(S,E)-N-(4-((3-chloro-4-fluorophenyl-1,2,3,4,5,6-13C6)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Related CAS	850140-72-6 (unlabelled) 439081-18-2 (unlabelled Z-isomer)