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Alectinib-[3,3,4,5,5-d5]

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Alectinib-[3,3,4,5,5-d5]

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General Information
Catalog: BLP-013430
Molecular Formula: C30H29D5N4O2
Molecular Weight: 487.65

Chemical Structure

Description	Labelled Alectinib. Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance.
Synonyms	Alecensa-d5; 9-Ethyl-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile-d5
IUPAC Name	9-ethyl-6,6-dimethyl-11-oxo-8-(3,3,4,5,5-pentadeuterio-4-morpholinopiperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Related CAS	1256580-46-7 (unlabelled)
Purity	>95%; 98% atom D

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