Name: Alfuzosin-[d7] Hydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-013016

CAS: 1276197-14-8

Molecular Formula: C19H21D7ClN5O4

Molecular Weight: 432.96

Chemical Structure

Description	Alfuzosin-[d7] Hydrochloride is the labelled salt of Alfuzosin, which is an α1 adrenergic receptor antagonist and could be used in the treatment of benign prostatic hyperplasia.
Synonyms	Alfuzosin D7 Hydrochloride; (±)-Alfuzosin-d7 HCl (tetrahydrofuroyl-d7); N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolynyl)methylamino]propyl]tetrahydro-2-furancarboxamide-d7 Hydrochloride; Alfoten-d7; SL 77499-10-d7; Urion-d7; Uroxatral-d7; Xatral-d7
IUPAC Name	N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]-2,3,3,4,4,5,5-heptadeuteriooxolane-2-carboxamide;hydrochloride
Related CAS	81403-68-1 (unlabelled) 81403-80-7 (unlabelled free base)
Canonical SMILES	CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC.Cl
InChI	InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H/i4D2,6D2,9D2,14D;
InChI Key	YTNKWDJILNVLGX-IMFUZPKQSA-N
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in Methanol (Slightly), Water (Slightly)
Appearance	White Solid
Storage	Store at -20°C under inert atmosphere

Alfuzosin-[d7] Hydrochloride, a deuterated analog of Alfuzosin utilized primarily in scientific research, serves as a versatile tool in various applications. Here are the key applications:

Pharmacokinetic Studies: Employing Alfuzosin-[d7] Hydrochloride in pharmacokinetic investigations allows researchers to comprehensively explore the absorption, distribution, metabolism, and excretion of drugs. Its deuterium labeling enables precise tracking within the body, distinguishing it from its non-labeled counterparts. This differentiation is crucial for studying intricate drug interactions and refining dosing strategies with meticulous attention to detail.

Bioavailability Assessment: Researchers leverage Alfuzosin-[d7] Hydrochloride to evaluate the bioavailability of pharmaceutical compounds. By analyzing the levels of deuterated and non-deuterated forms in biological samples, scientists can assess the drug’s effectiveness in being absorbed and reaching targeted tissues. This data plays a pivotal role in enhancing drug formulations and optimizing delivery mechanisms for enhanced therapeutic outcomes.

Metabolite Identification: The deuterium label present in Alfuzosin-[d7] Hydrochloride serves as a valuable asset in identifying and quantifying metabolites during metabolism studies. Its distinct mass facilitates the tracking of metabolic pathways, shedding light on the drug’s biotransformation processes. These insights aid in pinpointing potential metabolites that influence the drug’s efficacy and adverse effects, contributing to a deeper understanding of drug metabolism complexities.

Internal Standard in LC-MS/MS: Widely employed as an internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays, Alfuzosin-[d7] Hydrochloride plays a critical role in enhancing the accuracy and reliability of quantitative analyses. Its utilization as an internal standard ensures precise measurements of drug concentrations in pharmacological and clinical research settings, offering invaluable insights for informed decision-making and robust data interpretation.