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Alpelisib-[13C5,15N]

General Information
Catalog: BLP-000895
Molecular Formula: C14[13C]5H22F3N4[15N]O2S
Molecular Weight: 447.43
Chemical Structure
Alpelisib-[13C5,15N]
Description Alpelisib-[13C5,15N] is the labelled analogue of Alpelisib. Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Synonyms [13C5,15N]-Alpelisib; [13C5,15N]-BYL-719; (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl](2,3,4,5-13C4,1-15N)azolidine-1,2-dicarboxamide-2-13C
IUPAC Name (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-2,3,4,5-13C4-1-15N-1,2-dicarboxamide-2-13C
Related CAS 1217486-61-7 (unlabelled)
Canonical SMILES CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
InChI InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1/i4+1,5+1,8+1,12+1,15+1,27+1
InChI Key STUWGJZDJHPWGZ-GCUHJTDDSA-N
Purity 98%
Appearance White Solid

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