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AM 404-[d4]

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General Information
Catalog: BLP-003276
CAS: 1185244-71-6
Molecular Formula: C26H33D4NO2
Molecular Weight: 399.6

Chemical Structure

Description	AM 404-[d4] is a labelled analogue of AM 404. AM-404 is a selective inhibitor of the carrier-mediated transport of anandamide without affecting anandamide hydrolysis. AEM is also an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its reuptake into presynaptic neurons. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo.
Synonyms	(5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl-d4)-5,8,11,14-eicosatetraenamide; (all-Z)-N-(4-Hydroxyphenyl-d4)-5,8,11,14-eicosatetraenamide
IUPAC Name	(5Z,8Z,11Z,14Z)-N-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
Related CAS	183718-77-6 (unlabelled)
Canonical SMILES	CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)O
InChI	InChI=1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6-,10-9-,13-12-,16-15-/i20D,21D,22D,23D
InChI Key	IJBZOOZRAXHERC-GPETUTDJSA-N
Melting Point	48-50°C
Solubility	Soluble in Dichloromethane (Slightly), DMSO (Slightly)
Appearance	Light Brown Solid
Storage	Amber Vial, -20°C, under inert atmosphere