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Ambrisentan-[d10]

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General Information
Catalog: BLP-011780
CAS: 1046116-27-1
Molecular Formula: C22H12D10N2O4
Molecular Weight: 388.48

Chemical Structure

Description	Ambrisentan-[d10] is the labelled analogue of Ambrisentan, which is a non-peptide endothelin ETA receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).
Synonyms	Ambrisentan D10; (αS)-α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-(phenyl-2,3,4,5,6-d5)benzene-2,3,4,5,6-d5-propanoic Acid; BSF 208075-d10; LU 208075-d10
IUPAC Name	(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-bis(2,3,4,5,6-pentadeuteriophenyl)propanoic acid
Related CAS	177036-94-1 (unlabelled)
Canonical SMILES	CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI	InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1/i4D,5D,6D,7D,8D,9D,10D,11D,12D,13D
InChI Key	OUJTZYPIHDYQMC-KYBYSFRQSA-N
Melting Point	>160°C (dec.)
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance	White to Off-white Solid
Storage	Store at -20°C