CAS 1046116-27-1 Ambrisentan-[d10] - Isotope / BOC Sciences

General Information
Catalog: BLP-011780
CAS: 1046116-27-1
Molecular Formula: C22H12D10N2O4
Molecular Weight: 388.48

General Information

Catalog: BLP-011780

CAS: 1046116-27-1

Molecular Formula: C22H12D10N2O4

Molecular Weight: 388.48

Chemical Structure

Description	Ambrisentan-[d10] is the labelled analogue of Ambrisentan, which is a non-peptide endothelin ETA receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).
Synonyms	Ambrisentan D10; (αS)-α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-(phenyl-2,3,4,5,6-d5)benzene-2,3,4,5,6-d5-propanoic Acid; BSF 208075-d10; LU 208075-d10
IUPAC Name	(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-bis(2,3,4,5,6-pentadeuteriophenyl)propanoic acid
Related CAS	177036-94-1 (unlabelled)
Canonical SMILES	CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI	InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1/i4D,5D,6D,7D,8D,9D,10D,11D,12D,13D
InChI Key	OUJTZYPIHDYQMC-KYBYSFRQSA-N
Melting Point	>160°C (dec.)
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance	White to Off-white Solid
Storage	Store at -20°C

Ambrisentan-[d10], a deuterated variant of the endothelin receptor antagonist Ambrisentan, is a valuable asset in research settings. Here are some key applications of Ambrisentan-[d10]:

Pharmacokinetic Studies: Employing Ambrisentan-[d10] in pharmacokinetic studies allows researchers to meticulously track and quantify drug metabolism and distribution throughout the body. The incorporation of deuterated isotopes provides a stable labeling mechanism, facilitating clear differentiation from the non-deuterated parent compound via mass spectrometry. This distinction aids in precise determination of pharmacokinetic parameters, thereby enhancing the drug development pipeline.

Drug Interaction Studies: Uncover the nuances of Ambrisentan’s interactions with other substances through the lens of drug interaction studies utilizing Ambrisentan-[d10]. The deuterated form enables accurate discrimination between Ambrisentan and its metabolites, shedding light on metabolic pathways and potential drug-drug interactions. Deepening our understanding of these interactions is paramount for optimizing therapeutic regimens and ensuring patient safety.

Precision Medicine: Embark on a journey through the realm of precision medicine with Ambrisentan-[d10] as a guide. Explore individualized responses to drug therapy by investigating variations in drug response across different genetic backgrounds. By dissecting the pharmacokinetics and pharmacodynamics of Ambrisentan, researchers can pinpoint biomarkers predictive of patient responses, facilitating tailored treatment plans and enhancing therapeutic outcomes.

Bioanalytical Method Development: Unravel the intricate world of bioanalytical method development with the aid of Ambrisentan-[d10] as an internal standard. Utilizing deuterated standards ensures the precise quantification of Ambrisentan levels in biological samples via mass spectrometry. This meticulous approach elevates the reliability and reproducibility of analytical methods, playing a pivotal role in regulatory compliance and advancing clinical research endeavors.