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Apatinib-[d8] hydrochloride

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General Information
Catalog: BLP-013761
CAS: 2468771-44-8
Molecular Formula: C24H16D8ClN5O
Molecular Weight: 441.98

Chemical Structure

Description	Apatinib-[d8] hydrochloride is the labelled salt of Apatinib, which is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities.
Synonyms	Apatinib-d8 hydrochloride; N-[4-(1-Cyanocyclopentyl-d8)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide hydrochloride; YN968D1-d8 Hydrochloride
IUPAC Name	N-[4-(1-cyano-2,2,3,3,4,4,5,5-octadeuteriocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;hydrochloride
Related CAS	811803-05-1 (unlabelled free base) 2468771-43-7 (free base)
Canonical SMILES	C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4.Cl
InChI	InChI=1S/C24H23N5O.ClH/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18;/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30);1H/i1D2,2D2,11D2,12D2;
InChI Key	YJFMYZMORFXPKW-DBYQDOQESA-N
Melting Point	>192°C (dec.)
Purity	≥98%; ≥99% atom D
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance	Off-white to Pale Yellow Solid
Storage	Store at 2-8°C