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Apremilast-[d8]

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Apremilast-[d8]

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General Information
Catalog: BLP-003328
CAS: 1258597-45-3
Molecular Formula: C22H16D8N2O7S
Molecular Weight: 468.55

Chemical Structure

Description	Labelled Apremilast. Apremilast (CC-10004) is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast specifically inhibits PDE4 and inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells.
Synonyms	N-[2-[(1S)-1-[3-(Ethoxy-1,1,2,2,2-d5)-4-(methoxy-d3)phenyl]-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide; Apremilast d8
IUPAC Name	N-[2-[(1S)-2-methylsulfonyl-1-[3-(1,1,2,2,2-pentadeuterioethoxy)-4-(trideuteriomethoxy)phenyl]ethyl]-1,3-dioxoisoindol-4-yl]acetamide
Related CAS	608141-41-9 (unlabelled)
Canonical SMILES	CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
InChI	InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1/i1D3,3D3,5D2
InChI Key	IMOZEMNVLZVGJZ-OALDVYBXSA-N
Purity	> 98%