Artesunate-[13C,d4] - Isotope / BOC Sciences

General Information
Catalog: BLP-003344
Molecular Formula: C18[13C]H24D4O8
Molecular Weight: 389.44

General Information

Catalog: BLP-003344

Molecular Formula: C18[13C]H24D4O8

Molecular Weight: 389.44

Chemical Structure

Description	Artesunate-[13C,d4] is a labelled derivative of the natural product artemisinin which effectively kills the malarial parasites P. falciparum and P. vivax. It also kills trematodes of the species Schistosoma, providing protection against schistosomiasis.
Synonyms	4-{[9-(13C,2H3)methyl-1,5-dimethyl(9-2H)-11,14,15,16-tetraoxatetracyclo[103.1.0,.0,]hexadecan-10 yl]oxy}-4-oxobutanoic acid
IUPAC Name	4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-9-deuterio-1,5-dimethyl-9-(trideuterio(1-13C)methyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]-4-oxobutanoic acid
Related CAS	88495-63-0 (unlabelled)
Canonical SMILES	CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C
InChI	InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1/i2+1D3,11D
InChI Key	FIHJKUPKCHIPAT-ABQRHAIOSA-N

Artesunate-[13C,d4], a stable isotope-labeled derivative of artesunate, an antimalarial drug, offers unique advantages in various experimental and analytical settings. Here are key applications of Artesunate-[13C,d4], presented with high perplexity and burstiness:

Pharmacokinetic Studies: Delving into the intricate realm of pharmacokinetics, researchers employ Artesunate-[13C,d4] to unravel the drug's metabolic pathways and scrutinize its absorption, distribution, metabolism, and excretion profiles. The distinctive isotope labeling enables precise differentiation between the administered drug and its natural counterpart within the body, yielding invaluable insights into the drug's behavior and paving the way for optimal dosing strategies that ensure efficacy and safety.

Metabolomics Research: In the dynamic field of metabolomics, Artesunate-[13C,d4] emerges as a pivotal internal standard for quantifying the concentrations of artesunate and its metabolites in biological samples. Serving as a reference point, it elevates the precision and accuracy of analytical measurements, particularly in techniques like mass spectrometry. This precision is paramount for deciphering the biochemical repercussions of artesunate and fostering the evolution of superior antimalarial interventions.

Drug-Drug Interaction Studies: Unveiling the complexities of drug interactions, Artesunate-[13C,d4] takes center stage in studies exploring the interplay between artesunate and co-administered medications during malaria treatment. The strategic isotope labeling aids in differentiating artesunate from metabolites or drugs with similar masses in complex biological matrices, ensuring the safety and efficacy of combination therapies.

Isotope Labeling Research: Venturing into the realm of isotope labeling research, Artesunate-[13C,d4] emerges as a potent instrument for probing the isotopic effects on drug metabolism and action. Researchers delve into how isotopic integration influences pharmacological properties and the mechanism of action of artesunate, offering pathways for designing novel isotopic variants with potentially enhanced therapeutic profiles.