CAS 1398065-95-6 Atomoxetine-[d5] hydrochloride

General Information
Catalog: BLP-013546
CAS: 1398065-95-6
Molecular Formula: C17H17D5ClNO
Molecular Weight: 296.85

General Information

Catalog: BLP-013546

CAS: 1398065-95-6

Molecular Formula: C17H17D5ClNO

Molecular Weight: 296.85

Chemical Structure

Description	Atomoxetine-[d5] hydrochloride is the labelled salt of Atomoxetine. Atomoxetine is a norepinephrine (noradrenaline) reuptake inhibitor used to treat attention-deficit hyperactivity disorder (ADHD).
Synonyms	rac Atomoxetine-d5 Hydrochloride; Tomoxetine-d5 hydrochloride; LY 139603-d5; (R)-Tomoxetine-d5 hydrochloride
IUPAC Name	N-methyl-3-(2-methylphenoxy)-3-(2,3,4,5,6-pentadeuteriophenyl)propan-1-amine;hydrochloride
Related CAS	82248-59-7 (unlabelled) 83015-26-3 (unlabelled free base) 1129477-98-0 (free base)
Canonical SMILES	CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl
InChI	InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/i3D,4D,5D,9D,10D;
InChI Key	LUCXVPAZUDVVBT-JMWQIYKASA-N
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in Chloroform (Slightly), Methanol (Slightly)
Appearance	Light Beige Solid
Storage	Store at 2-8°C

Atomoxetine-[d5] hydrochloride, a labeled compound utilized in diverse research applications within pharmacology and neuroscience, offers a realm of scientific possibilities. Here are the key applications of Atomoxetine-[d5] hydrochloride:

Pharmacokinetic Studies: Delving into the intricate world of pharmacokinetics, Atomoxetine-[d5] hydrochloride becomes a pivotal tool for tracking and quantifying the absorption, distribution, metabolism, and excretion pathways of atomoxetine within the body. By harnessing the power of its deuterated form, researchers gain the ability to discern it from endogenous compounds in biological samples, thus shedding light on the drug’s behaviors and facilitating the optimization of dosing regimens.

Neurochemical Research: Unveiling the mysteries of neurotransmitter systems, Atomoxetine-[d5] emerges as a potent agent for exploring the impact of atomoxetine on neuronal signaling pathways, particularly the norepinephrine transporter. Through the deployment of Atomoxetine-[d5], researchers embark on a journey to dissect the drug’s influence on neurotransmitter levels and neuronal excitability, illuminating its therapeutic mechanisms in conditions like Attention Deficit Hyperactivity Disorder (ADHD) with unparalleled depth.

Drug-Drug Interaction Studies: Navigating the intricacies of drug interactions, Atomoxetine-[d5] hydrochloride takes center stage in unraveling the potential interplays between atomoxetine and other pharmaceutical agents. Through the strategic co-administration of this labeled compound alongside various medications, researchers embark on a quest to unveil and quantify the potential interactions that might impact drug efficacy and safety. This meticulous exploration is paramount in the development of safe medication regimens and the prevention of adverse effects, safeguarding patient well-being.

Analytical Method Development: Serving as the cornerstone in the realm of analytical chemistry, Atomoxetine-[d5] hydrochloride assumes the role of a reference standard in the genesis and validation of analytical methodologies for the detection and quantification of atomoxetine in biological matrices. By harnessing the precision and accuracy offered by the labeled compound, researchers secure the reliability of bioanalytical assays, thus fortifying the foundation of pharmacokinetic and pharmacodynamic investigations with unwavering certainty and meticulous attention to detail.