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(±)-Atropine-[d3] (N-methyl-[d3])

General Information
Catalog: BLP-009660
CAS: 1276197-36-4
Molecular Formula: C17H20D3NO
Molecular Weight: 292.39
Chemical Structure
(±)-Atropine-[d3] (N-methyl-[d3])
Description One of the isotopic labelled form of (±)-Atropine, which could be used as a pesticide poisoning and as a muscle relaxant.
Synonyms (±)-Atropine-d3 (N-methyl-d3)
Related CAS 51-55-8 (unlabelled)
Purity 95% by HPLC; 98% atom D

(±)-Atropine-[d3] (N-methyl-[d3]) is a deuterium-labeled form of atropine, a well-known tropane alkaloid with various applications. Here are some key applications of (±)-Atropine-[d3] (N-methyl-[d3]):

Pharmacokinetic Studies: (±)-Atropine-[d3] is used in pharmacokinetic studies to track the absorption, distribution, metabolism, and excretion of atropine in the body. Its deuterium label allows for precise and sensitive detection using mass spectrometry. This helps in understanding the drug’s behavior and optimizing dosing regimens.

Metabolite Analysis: By using (±)-Atropine-[d3], researchers can study the metabolic pathways of atropine in various organisms. The deuterium label acts as a tracer, making it easier to identify and quantify atropine metabolites in biological samples. This application is crucial for assessing the drug’s safety and efficacy.

Receptor Binding Studies: (±)-Atropine-[d3] is used to study the interaction of atropine with muscarinic acetylcholine receptors. Researchers can measure the binding affinity and kinetics using radiolabeled or mass spectrometry techniques. This information is valuable for developing drugs that target these receptors for therapeutic purposes.

Toxicology Research: The deuterium-labeled atropine helps in toxicology studies by providing detailed information on the toxicokinetic properties of atropine. Researchers use it to investigate the drug’s potential toxic effects and to establish safe exposure limits. This knowledge is essential for ensuring the safe use of atropine in medical and regulatory settings.

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