Name: Avapritinib-[d3]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-014998

CAS: 2408934-57-4

Molecular Formula: C26H24D3FN10

Molecular Weight: 501.58

Chemical Structure

Description	Avapritinib-[d3] is a labelled form of Avapritinib, which is a kinase inhibitor used for the treatment of advanced systemic mastocytosis and indolent systemic mastocytosis.
Synonyms	(S)-1-(4-Fluorophenyl)-1-(2-(4-(6-(1-(methyl-d3)-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine; Avapritinib D3; (αS)-α-(4-Fluorophenyl)-α-methyl-2-[4-[6-(1-(methyl-d3)-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl]-5-pyrimidinemethanamine; (1S)-1-(4-fluorophenyl)-1-(2-{4-[6-(1-(methyl-d3)-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl}pyrimidin-5-yl)ethan-1-amine; Avapritinib-d3; Ayvakit-d3; Ayvakyt-d3; BLU 285-d3
IUPAC Name	(1S)-1-(4-fluorophenyl)-1-[2-[4-[6-[1-(trideuteriomethyl)pyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine
Related CAS	1703793-34-3 (unlabelled)
Canonical SMILES	[2H]C([2H])([2H])N1C=C(C=N1)C2=CN3C(=C2)C(=NC=N3)N4CCN(CC4)C5=NC=C(C=N5)[C@](C)(C6=CC=C(C=C6)F)N
InChI	InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1/i2D3
InChI Key	DWYRIWUZIJHQKQ-SVJJMHFFSA-N
Purity	>95%
Storage	Store at 2-8 °C