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Axitinib-[13C,d3]

General Information
Catalog: BLP-003540
CAS: 1261432-00-1
Molecular Formula: C21[13C]H15D3N4OS
Molecular Weight: 390.48
Chemical Structure
Axitinib-[13C,d3]
Description Axitinib-[13C,d3] is a labelled Axitinib. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models.
Synonyms [13C,2H3]-N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; (E)-N-(methyl-13C-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
IUPAC Name 2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]-N-(trideuterio(1-13C)methyl)benzamide
Related CAS 319460-85-0 (unlabelled)
Canonical SMILES CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
InChI InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+/i1+1D3
InChI Key RITAVMQDGBJQJZ-QUYHSVBSSA-N
Purity > 98%
Appearance White Solid
Storage -20°C

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