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Azacitidine-[15N4]

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General Information
Catalog: BLP-001444
Molecular Formula: C8H12[15N]4O5
Molecular Weight: 248.18

Chemical Structure

Description	Labelled Azacitidine. Azacitidine (Vidaza) is a chemotherapy drug used to treat conditions that affect the blood and the bone marrow, called myelodysplastic syndromes (MDS). It may also be used to treat other cancers, such as acute myeloid leukaemia (AML) or chronic myelomonocytic leukaemia (CMML). It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~0.4 μM for inhibiting proliferation of various cancer cell lines). It can also act as a demethylating agent by inhibiting DNA methyltransferase.
Related CAS	320-67-2 (unlabelled)
Purity	98%; 99% atom 15N
Solubility	Soluble in Dimethyl sulfoxide, Ethanol or Water