CAS 2983160-40-1 Azithromycin-[6-methyl-13C,d3]

General Information
Catalog: BLP-003542
CAS: 2983160-40-1
Molecular Formula: C37[13C]H69D3N2O12
Molecular Weight: 753.01

General Information

Catalog: BLP-003542

CAS: 2983160-40-1

Molecular Formula: C37[13C]H69D3N2O12

Molecular Weight: 753.01

Chemical Structure

Description	One of the isotopic labelled form of Azithromycin, which is an azalide macrolide antibiotic.
Synonyms	Azithromycin-13CD3; Azithromycin-13C,d3; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-6-(methyl-13C-d3)-1-oxa-6-azacyclopentadecan-15-one; CP-62993-13C,d3; XZ-450-13C,d3; Azitrocin-13C,d3; Ribotrex-13C,d3; Sumamed-13C,d3; Trozocina-13C,d3; Zithromaz-13C,d3; Zitromax-13C,d3
IUPAC Name	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-6-(trideuterio(1-13C)methyl)-1-oxa-6-azacyclopentadecan-15-one
Related CAS	83905-01-5 (unlabelled)
Canonical SMILES	CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
InChI	InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1/i13+1D3
InChI Key	MQTOSJVFKKJCRP-ACLAECRHSA-N
Purity	95% by HPLC; 98% atom D/13C
Storage	Store at 2-8 °C

Azithromycin-[13C,d3] is a labeled antibiotic used in various research applications. Here are some key applications of Azithromycin-[13C,d3]:

Pharmacokinetic Studies: Azithromycin-[13C,d3] is employed in pharmacokinetic studies to track the absorption, distribution, metabolism, and excretion of the antibiotic. The labeled compound allows researchers to accurately measure and quantify the presence of azithromycin in biological samples using mass spectrometry. This provides detailed insights into the drug’s behavior within the body, aiding in the optimization of dosing regimens.

Metabolic Pathway Analysis: The use of Azithromycin-[13C,d3] facilitates the study of metabolic pathways involving azithromycin within organisms. By tracking the 13C and deuterium labels, researchers can identify and characterize the metabolic products formed during the drug’s metabolism. This information is critical for understanding drug interactions and potential side effects.

Microbial Resistance Research: Azithromycin-[13C,d3] is valuable in studying the mechanisms of microbial resistance. Researchers can use this labeled antibiotic to investigate how bacteria metabolize azithromycin and develop resistance to it. This knowledge is crucial for designing new antibiotics and strategies to combat antibiotic-resistant bacteria.

Development of Analytical Methods: Azithromycin-[13C,d3] is used to develop and validate analytical methods for quantifying azithromycin in various matrices. Its incorporation into standard methods improves the accuracy and reliability of analytical techniques such as liquid chromatography-mass spectrometry (LC-MS). This ensures precise measurement of azithromycin levels in clinical and research settings.