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Bictegravir-[d7]

General Information
Catalog: BLP-013433
Molecular Formula: C21H11D7F3N3O5
Molecular Weight: 456.4
Chemical Structure
Bictegravir-[d7]
Description Labelled analog of Bictegravir. Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection.
Synonyms Bictegravir-d7; GS-9883-d7
Related CAS 1611493-60-7 (unlabelled)
Purity >95%; 98% atom D

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