CAS 1840942-14-4 C18 Ceramide (d18:1/18:0)-[d7]

General Information
Catalog: BLP-011237
CAS: 1840942-14-4
Molecular Formula: C36H64D7NO3
Molecular Weight: 573.0

General Information

Catalog: BLP-011237

CAS: 1840942-14-4

Molecular Formula: C36H64D7NO3

Molecular Weight: 573.0

Chemical Structure

Description	C18 Ceramide (d18:1/18:0)-[d7] is the labelled analogue of C18 Ceramide, which is an endogenous biologically active sphingolipid.
Synonyms	N-stearoyl-D-erythro-sphingosine (d7)
IUPAC Name	N-[(E,2S,3R)-16,16,17,17,18,18,18-heptadeuterio-1,3-dihydroxyoctadec-4-en-2-yl]octadecanamide
Canonical SMILES	CCCCCCCCCCCCCCCCCC(=O)NC(CO)C(C=CCCCCCCCCCCCCC)O
InChI	InChI=1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1/i2D3,4D2,6D2
InChI Key	VODZWWMEJITOND-MUVBWDEFSA-N
Boiling Point	694.5±55.0 °C at 760 mmHg
Purity	99% by CP; 99% atom D
Density	0.9±0.1 g/cm3
Storage	Store at -20°C

C18 Ceramide (d18:1/18:0)-[d7] is a stable isotope-labeled ceramide renowned for its specific structural properties utilized in diverse bioscience research applications. Here are key applications of C18 Ceramide (d18:1/18:0)-[d7] presented with high perplexity and burstiness:

Lipidomics Studies: Positioned at the forefront of lipidomics, C18 Ceramide (d18:1/18:0)-[d7] plays a pivotal role in analyzing and quantifying ceramide levels within complex biological samples. Its stable isotope label distinguishes it from native ceramides, ensuring precise mass spectrometry analysis. This deeper exploration sheds light on lipid metabolism and its implications in diseases like cancer and cardiovascular disorders, enriching our understanding of cellular processes.

Signal Transduction Research: Delving into cellular signaling pathways, ceramides emerge as crucial bioactive lipids. C18 Ceramide (d18:1/18:0)-[d7] emerges as a valuable tool in unraveling the roles of ceramides in processes like apoptosis, inflammation, and cell stress responses. By probing how this labeled ceramide influences signaling pathways, researchers unearth potential therapeutic targets for intervening in diseases, paving the way for innovative treatment strategies.

Biophysical Studies: In the realm of membrane biophysics, C18 Ceramide (d18:1/18:0)-[d7] serves as a key element in deciphering the structural organization of lipid bilayers. Its integration into model membranes facilitates the exploration of ceramides' impact on membrane properties such as fluidity and permeability. These profound studies offer insights into ceramides' role in upholding cellular integrity and function, enhancing our understanding of fundamental biological processes.

Quantitative Proteomics: Within proteomics, this labeled ceramide serves as a cornerstone in studying protein-lipid interactions, acting as an internal standard for quantification. By enabling the assessment of proteins binding to ceramide-rich domains using advanced techniques like LC-MS/MS, this application plays a critical role in mapping interactions that influence cellular processes and disease mechanisms, advancing our knowledge of cellular communication pathways.