CAS 1276197-23-9 Chlorpromazine-[d6] Oxalate

General Information
Catalog: BLP-011559
CAS: 1276197-23-9
Molecular Formula: C17H13D6ClN2S.C2H2O4
Molecular Weight: 414.94

General Information

Catalog: BLP-011559

CAS: 1276197-23-9

Molecular Formula: C17H13D6ClN2S.C2H2O4

Molecular Weight: 414.94

Chemical Structure

Description	Chlorpromazine-[d6] oxalate is the labelled salt of Chlorpromazine. Chlorpromazine is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia.
Synonyms	Chlorpromazine-(dimethyl-d6) oxalate; Chlorpromazine-d6 Oxalate (N,N-dimethyl-d6); Thorazine-d6 Oxalate; Largactil-d6 Oxalate; Contomin-d6 Oxalate; Chlorderazin-d6 Oxalate; Aminazine-d6 Oxalate
IUPAC Name	3-(2-chlorophenothiazin-10-yl)-N,N-bis(trideuteriomethyl)propan-1-amine;oxalic acid
Related CAS	1019646-35-5 (unlabelled) 50-53-3 (unlabelled free base)
Isomeric SMILES	[2H]C([2H])([2H])N(CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)C([2H])([2H])[2H].C(=O)(C(=O)O)O
Canonical SMILES	CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.C(=O)(C(=O)O)O
InChI	InChI=1S/C17H19ClN2S.C2H2O4/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;3-1(4)2(5)6/h3-4,6-9,12H,5,10-11H2,1-2H3;(H,3,4)(H,5,6)/i1D3,2D3;
InChI Key	FZNQRUYAXGKACN-TXHXQZCNSA-N
Boiling Point	200-205°C
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in Chloroform, Methanol (Slightly)
Appearance	Off-white Solid
Storage	Store at 2-8°C under inert atmosphere

Chlorpromazine-[d6] Oxalate, a deuterated variant of the antipsychotic Chlorpromazine, finds diverse applications in research and preclinical settings. Here are the key applications:

Pharmacokinetic Studies: Chlorpromazine-[d6] Oxalate plays a pivotal role in pharmacokinetic investigations, shedding light on the absorption, distribution, metabolism, and excretion processes of Chlorpromazine. Its deuterated nature allows for precise tracking and differentiation from the non-deuterated drug in biological samples, offering detailed insights into the drug’s pharmacokinetic behavior.

Metabolism Research: Scientists utilize Chlorpromazine-[d6] Oxalate to explore the intricate metabolic pathways of Chlorpromazine within the human body. The labeled molecule aids in tracing metabolic intermediates and end products using advanced mass spectrometry techniques. This application is essential for deciphering drug metabolism intricacies and uncovering potential metabolic interactions that impact drug efficacy.

Drug Interaction Studies: Chlorpromazine-[d6] Oxalate serves as a valuable tool in probing potential drug-drug interactions. By discerning Chlorpromazine-[d6] from other compounds in complex biological matrices, researchers unveil whether concurrent medications influence Chlorpromazine’s pharmacokinetics or therapeutic effectiveness. This knowledge is critical for optimizing treatment regimens and enhancing patient outcomes in clinical practice.

Biomarker Quantification: In clinical investigations, Chlorpromazine-[d6] Oxalate acts as an internal standard for precisely quantifying Chlorpromazine levels in biological specimens like plasma and urine. Its presence ensures accurate and reproducible measurement of Chlorpromazine concentration, pivotal for therapeutic drug monitoring and toxicological assessments.