Cinnarizine-[d8] Dihydrochloride

Cinnarizine-[d8] Dihydrochloride, a deuterated variant of cinnarizine, widely utilized in bioscience research, offers diverse applications. Here are the key uses of Cinnarizine-[d8] Dihydrochloride:

Pharmacokinetic Studies: Employed in pharmacokinetic studies, Cinnarizine-[d8] Dihydrochloride plays a crucial role in tracing the absorption, distribution, metabolism, and excretion (ADME) of cinnarizine within biological systems. The deuterated form enables precise mass spectrometric analysis, distinguishing it from endogenous compounds and delivering accurate insights into the drug’s in vivo behavior. This aids in optimizing dosages and assessing safety parameters.

Drug Metabolism Research: Within drug metabolism research, Cinnarizine-[d8] Dihydrochloride acts as an internal standard for investigating the metabolic pathways of cinnarizine. Researchers leverage it to detect and quantify metabolites, comprehend enzyme interactions, and evaluate potential drug-drug interactions. This data is pivotal for understanding the metabolic destiny and potential adverse effects associated with cinnarizine usage.

Isotope Dilution Analysis: Integral to isotope dilution analysis, Cinnarizine-[d8] Dihydrochloride serves as a quantitative tool in bioanalytical chemistry. By spiking biological samples with this deuterated compound, scientists achieve precise quantification of cinnarizine concentrations, enhancing the accuracy and reliability of pharmacokinetic and bioavailability assessments.

Stability Testing: In the realm of stability testing, Cinnarizine-[d8] Dihydrochloride plays a vital role in monitoring the stability of cinnarizine across various environmental conditions. Utilizing the deuterated form aids in discerning between the parent compound and any degradation products, ensuring the quality and shelf-life of pharmaceutical formulations containing cinnarizine are maintained at optimal levels.