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Colchicine-[d6]

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General Information
Catalog: BLP-012275
CAS: 1217651-73-4
Molecular Formula: C22H19D6NO6
Molecular Weight: 405.47

Chemical Structure

Description	Colchicine-[d6] is an isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin. It also induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Synonyms	N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide-d6; (-)-Colchicine-d6; Colchineos-d6; Colchisol-d6; Colcin-d6; Colsaloid-d6; Condylon-d6; NSC 757-d6
IUPAC Name	2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Related CAS	64-86-8 (unlabelled)
Canonical SMILES	CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
InChI	InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3,2D3
InChI Key	IAKHMKGGTNLKSZ-BLYUGYDFSA-N
Melting Point	139-155°C
Purity	97% by HPLC; 97% atom D
Solubility	Soluble in Chloroform, Methanol, Water
Appearance	Light Yellow Solid
Storage	Store at -20°C