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Application Area
Environmental
Environmental

Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.

Clinical diagnostic
Clinical diagnostic

In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.

Organic Chemistry
Organic Chemistry

Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.

Metabolic Research
Metabolic Research

Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.

Colchicine-[d6]

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General Information
Catalog: BLP-012275
CAS: 1217651-73-4
Molecular Formula: C22H19D6NO6
Molecular Weight: 405.47
Chemical Structure
Colchicine-[d6]
Description Colchicine-[d6] is an isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin. It also induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Synonyms N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide-d6; (-)-Colchicine-d6; Colchineos-d6; Colchisol-d6; Colcin-d6; Colsaloid-d6; Condylon-d6; NSC 757-d6
IUPAC Name 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Related CAS 64-86-8 (unlabelled)
Canonical SMILES CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3,2D3
InChI Key IAKHMKGGTNLKSZ-BLYUGYDFSA-N
Melting Point 139-155°C
Purity 97% by HPLC; 97% atom D
Solubility Soluble in Chloroform, Methanol, Water
Appearance Light Yellow Solid
Storage Store at -20°C
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