Name: Crizotinib-[d5]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-012277

CAS: 1395950-48-7

Molecular Formula: C21H17D5Cl2FN5O

Molecular Weight: 455.37

Chemical Structure

Description	Crizotinib-d5 is a labelled Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
Synonyms	Crizotinib D5; 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-d4)-1H-pyrazol-4-yl]-2-pyridinamine-d5; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-ylamine-d5; PF 02341066-d5; PF 2341066-d5
IUPAC Name	3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-6-{1-[(2,2,4,6,6-2H5)-4-piperidinyl]-1H-pyrazol-4-yl}-2-pyridinamine
Related CAS	877399-52-5 (unlabelled)
Canonical SMILES	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
InChI	InChI=1S/C21H22Cl2FN5O/c1-12(19-15(22)2-3-16(24)20(19)23)30-18-5-4-17(28-21(18)25)13-10-27-29(11-13)14-6-8-26-9-7-14/h2-5,10-12,14,26H,6-9H2,1H3,(H2,25,28)/t12-/m1/s1/i8D2,9D2,14D
InChI Key	ZSDTZQWYOPVQMX-XDVIJSJVSA-N
Boiling Point	619.7±55.0 °C at 760 mmHg
Melting Point	200-202°C (dec.)
Purity	95% by HPLC; 95% atom D
Density	1.5±0.1 g/cm3
Appearance	Light Tan Solid