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D-mannose-[2-d]

General Information
Catalog: BLP-007011
Molecular Formula: C6H11DO6
Molecular Weight: 181.16
Chemical Structure
D-mannose-[2-d]
Description D-Mannose-[2-d] is a labeled analog of D-Mannose. D-mannose is important in the glycosylation of molecules. It is involved in N and O glycosylation of bovine. It is also used for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A.
Synonyms D-[2-2H]mannose; D-mannose-2-d; D-[2-D]mannose
IUPAC Name (3S,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-d-2,3,4,5-tetraol
Related CAS 3458-28-4 (unlabelled)
Solubility Soluble in Methanol, Water
Appearance White to Off-white Solid
Storage Store at -20°C

D-mannose-[2-d], a deuterated variant of the sugar mannose, boasts distinctive properties with diverse applications in the field of bioscience. Here are the key applications of D-mannose-[2-d]:

Urinary Tract Infection (UTI) Treatment: Embracing a natural therapeutic approach, D-mannose-[2-d] emerges as a pivotal agent in both preventing and treating urinary tract infections. Its mechanism involves thwarting bacterial adhesion to the urinary tract lining, thereby curbing the incidence of infections. This alternative treatment is especially advantageous for patients seeking options beyond conventional antibiotic therapies.

Glycoprotein Research: Delving into the realms of biochemical exploration, D-mannose-[2-d] finds utility in probing glycoprotein synthesis and processing. Through the incorporation of deuterated mannose into glycoproteins, researchers embark on a journey to trace and dissect protein glycosylation patterns. This endeavor contributes to elucidating protein folding dynamics, stability, and interplays within diverse biological milieus.

Metabolic Pathway Studies: Serving as a pivotal tracer in metabolic investigations, D-mannose-[2-d] enables scientists to delve into the intricacies of mannose metabolism. By leveraging this labeled sugar, researchers illuminate the integration of mannose into various biosynthetic pathways, shedding light on the roles of mannose in cellular functions and disease mechanisms.

Nutraceuticals: Nurturing health with targeted precision, D-mannose-[2-d] finds its way into dietary supplements renowned for their potential health benefits. As a naturally occurring sugar, it is harnessed to bolster digestive health and uphold the balance of intestinal flora. Its nuanced effects, coupled with minimal toxicity, position it as a key ingredient in the realm of functional foods and nutraceutical blends.

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