D-mannose-[2,3,4,5,6-13C5]

D-mannose-[2,3,4,5,6-13C5], a carbon-13 labeled compound, finds diverse applications in biochemical and medical research. Here are the key applications of D-mannose-[2,3,4,5,6-13C5]:

Metabolic Flux Analysis: Delving into metabolic intricacies, researchers harness D-mannose-[2,3,4,5,6-13C5] to dissect and quantify sugar pathways within cells. By using carbon-13 labeled D-mannose, scientists can meticulously trace the molecule's journey into metabolic intermediates. This nuanced approach sheds light on the dynamic nature of carbohydrate metabolism and the pivotal role of mannose in an array of biosynthetic processes.

Glycoprotein Research: Taking a deep dive into glycoprotein dynamics, researchers leverage D-mannose-[2,3,4,5,6-13C5] to explore the intricate world of glycoprotein synthesis and remodeling. By employing this labeled sugar, scientists unravel the incorporation of mannose into glycoproteins, offering valuable insights into mannose's impact on protein folding and trafficking. This line of research is critical for unraveling diseases linked to glycoprotein misfolding and crafting innovative therapeutic interventions.

MRI and NMR Spectroscopy: In the realm of advanced imaging techniques, D-mannose-[2,3,4,5,6-13C5] stands out as a crucial tool for magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) spectroscopy. Leveraging the enriched signal from the carbon-13 isotope, these methodologies unveil detailed structural and functional information about complex biological systems. This avenue of exploration facilitates non-invasive scrutiny of metabolic processes and fuels the development of cutting-edge diagnostic modalities.

Cancer Metabolism Studies: Unveiling the metabolic nuances of cancer, researchers employ D-mannose-[2,3,4,5,6-13C5] in targeted investigations into cancer metabolism, where aberrant sugar metabolism is a hallmark of many malignancies. Through the use of labeled D-mannose, scientists can meticulously trace the metabolic pathways fueling the growth and survival of cancer cells. This invaluable data plays a pivotal role in pinpointing novel therapeutic targets and unraveling the metabolic vulnerabilities that underpin cancer progression.