D-2-Aminobutyric acid-[2,3,3,4,4,4-d6]

D-2-Aminobutyric acid-[2,3,3,4,4,4-d6], a stable isotope-labeled analog of D-2-aminobutyric acid, finds diverse scientific applications. Here are the key applications:

Metabolic Tracing: Researchers utilize this compound in metabolic tracing studies to explore intricate metabolic pathways and fluxes. By introducing the labeled analog into biological systems, scientists can trace its conversion and identify intermediates. This aids in unraveling the complexities of metabolic networks and enzyme activities, shedding light on the inner workings of cellular metabolism.

Pharmacokinetics: In pharmacokinetic investigations, D-2-Aminobutyric acid-[2,3,3,4,4,4-d6] plays a crucial role in evaluating the absorption, distribution, metabolism, and excretion (ADME) of drug compounds. The stable isotope label enables precise quantification using mass spectrometry, a vital aspect of drug development and assessing the bioavailability of pharmaceutical agents. This sophisticated technique is pivotal in understanding how drugs interact within the body.

Quantitative Proteomics: Within the realm of proteomics, isotope-labeled amino acids like D-2-Aminobutyric acid-[2,3,3,4,4,4-d6] are integral for quantitative mass spectrometry-based methodologies such as SILAC (Stable Isotope Labeling by Amino acids in Cell culture). This strategy enables precise measurement of protein abundance and fluctuations under different experimental conditions, facilitating biomarker discovery and enhancing comprehension of cellular responses. Such detailed proteomic analyses offer valuable insights into cellular dynamics.

Neuroscience Research: Beyond its applications in metabolism and proteomics, this compound plays a significant role in neuroscience research. By studying its integration and metabolism in neural tissues, researchers can gain insights into neurotransmitter synthesis and amino acid transport, unraveling the intricate mechanisms underlying neurological disorders. This research contributes to a deeper understanding of brain function and potential therapeutic targets for neurological conditions.