D-ribose-[3,4,5-13C3]

D-ribose-[3,4,5-13C3], an isotopically labeled variant of D-ribose, finds diverse applications in scientific research. Here are the key applications:

Metabolic Flux Analysis: Employing D-ribose-[3,4,5-13C3] in metabolic flux analysis enables the tracing of carbon atom pathways in cellular metabolism. By introducing this labeled compound into cells, researchers can meticulously monitor the movement and alteration of carbon across various metabolic reactions. This data plays a pivotal role in unraveling the intricate web of metabolic networks and intracellular dynamics.

NMR Spectroscopy: Within the domain of nuclear magnetic resonance (NMR) spectroscopy, D-ribose-[3,4,5-13C3] assumes a critical role as an isotopic tracer. The incorporation of carbon-13 isotopes facilitates in-depth structural and dynamic analyses of molecules containing ribose. Researchers can generate high-resolution spectra to delve into the conformation of nucleotides, nucleic acids, and other biomolecules, shedding light on their complex structures.

Biochemical Research: In the realm of biochemical investigations, D-ribose-[3,4,5-13C3] serves as a valuable tool for probing ribose metabolism and its involvement in cellular processes. By leveraging this labeled compound, scientists can explore the synthesis, breakdown, and utilization of ribose within cells. This understanding contributes significantly to the comprehension of cellular energy production and nucleotide biosynthesis, providing insights into fundamental biological processes.

Drug Metabolism Studies: The use of D-ribose-[3,4,5-13C3] in pharmacokinetic and drug metabolism studies allows for the examination of the disposition of ribose-modified drugs. The isotopic labeling aids in tracking the metabolic pathways of these compounds in the body, offering crucial insights into drug efficacy, safety, and the optimization of therapeutic approaches. This information plays a key role in advancing our understanding of drug metabolism and refining treatment strategies.