D-Mannose-[5-13C]

D-Mannose-[5-13C], a stable isotope-labeled sugar, finds widespread use in various research fields and applications. Here are the key applications of D-Mannose-[5-13C]:

Metabolic Flux Analysis: Employing D-Mannose-[5-13C] in metabolic flux analysis unveils the intricate pathways of mannose metabolism across diverse organisms. By scrutinizing the integration of the 13C isotope, researchers unveil the intricate dynamics of mannose utilization and metabolic networks. This insight proves invaluable in deciphering cellular metabolism intricacies and pinpointing potential metabolic bottlenecks.

Glycoprotein Research: Within glycoprotein research, D-Mannose-[5-13C] plays a pivotal role in delving into the biosynthesis and modification of glycoproteins. The incorporation of labeled mannose into glycan structures enables a profound analysis of glycosylation patterns using cutting-edge techniques like mass spectrometry and NMR spectroscopy. This application stands as a cornerstone for understanding the pivotal roles played by glycoproteins in cell signaling cascades and disease progression.

Drug Metabolism Studies: Delving into drug metabolism, D-Mannose-[5-13C] provides vital insights into how specific pharmaceutical compounds impact mannose metabolism and associated pathways. By introducing the labeled sugar and monitoring its metabolic journey, scientists can gauge drug influences on metabolic fluxes and potential side effects. This knowledge forms the bedrock for crafting safe and efficacious pharmaceutical interventions.

Microbial Pathogenesis: In the realm of microbial pathogenesis, the usage of D-Mannose-[5-13C] sheds light on how pathogenic microorganisms metabolize mannose during infection episodes. Charting the course of labeled mannose utilization helps decipher the intricate nuances of microbial metabolism and unearth unique metabolic pathways that can serve as prime targets for treatment modalities. Such investigations play a pivotal role in formulating strategic interventions to combat infections stemming from mannose-utilizing pathogens.