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D-alpha-Hydroxyglutaric acid-[13C5] disodium salt

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General Information
Catalog: BLP-000531
CAS: 1648909-80-1
Molecular Formula: [13C]5H6Na2O5
Molecular Weight: 197.04

Chemical Structure

Description	D-alpha-Hydroxyglutaric acid-[13C5] disodium salt is the labelled analogue of Disodium (R)-2-Hydroxyglutarate. Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79.
Synonyms	2-Hydroxyglutarate-13C5 disodium salt; (R)-2-Hydroxypentanedioic acid-13C5 disodium salt; Disodium (R)-2-hydroxyglutarate-13C5; D-α-Hydroxyglutaric acid-13C5 disodium salt; (2R)-2-Hydroxyglutaric Acid Disodium Salt-13C5; (R)-2-Hydroxyglutaric Acid Disodium Salt-13C5; (R)-α-Hydroxyglutaric Acid Disodium Salt-13C5; D-2-Hydroxyglutaric Acid Disodium Salt-13C5; D-alpha-Hydroxyglutaric acid-13C5 disodium salt
IUPAC Name	disodium;(2R)-2-hydroxy(1,2,3,4,5-13C5)pentanedioate
Related CAS	103404-90-6 (unlabelled)
Canonical SMILES	C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+]
InChI	InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1/i1+1,2+1,3+1,4+1,5+1;;
InChI Key	DZHFTEDSQFPDPP-JVBXKYRZSA-L
Melting Point	> 300 °C
Purity	≥ 94% (CP); ≥ 99% atom 13C
Solubility	Slightly soluble in Water (Sonicated)
Appearance	White to Off-white Solid
Storage	2-8 °C under inert atmosphere