| Description |
D-alpha-Hydroxyglutaric acid-[13C5] disodium salt is the labelled analogue of Disodium (R)-2-Hydroxyglutarate. Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79. |
| Synonyms |
2-Hydroxyglutarate-13C5 disodium salt; (R)-2-Hydroxypentanedioic acid-13C5 disodium salt; Disodium (R)-2-hydroxyglutarate-13C5; D-α-Hydroxyglutaric acid-13C5 disodium salt; (2R)-2-Hydroxyglutaric Acid Disodium Salt-13C5; (R)-2-Hydroxyglutaric Acid Disodium Salt-13C5; (R)-α-Hydroxyglutaric Acid Disodium Salt-13C5; D-2-Hydroxyglutaric Acid Disodium Salt-13C5; D-alpha-Hydroxyglutaric acid-13C5 disodium salt |
| IUPAC Name |
disodium;(2R)-2-hydroxy(1,2,3,4,5-13C5)pentanedioate |
| Related CAS |
103404-90-6 (unlabelled)
|
| Canonical SMILES |
C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+] |
| InChI |
InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1/i1+1,2+1,3+1,4+1,5+1;; |
| InChI Key |
DZHFTEDSQFPDPP-JVBXKYRZSA-L |
| Melting Point |
> 300 °C |
| Purity |
≥ 94% (CP); ≥ 99% atom 13C |
| Solubility |
Slightly soluble in Water (Sonicated) |
| Appearance |
White to Off-white Solid |
| Storage |
2-8 °C under inert atmosphere |
![D-alpha-Hydroxyglutaric acid-[13C5] disodium salt](/isotope.v1/images/structure-default.jpg)
