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D-Lyxose-[1-13C]

General Information
Catalog: BLP-009249
CAS: 70849-22-8
Molecular Formula: C4[13C]H10O5
Molecular Weight: 151.12
Chemical Structure
D-Lyxose-[1-13C]
Description One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase.
Synonyms D-[1-13C]lyxose
IUPAC Name (2S,3S,4R)-2,3,4,5-tetrahydroxy(1-13C)pentanal
Related CAS 1114-34-7 (unlabelled)
Canonical SMILES C(C(C(C(C=O)O)O)O)O
InChI InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4-,5-/m1/s1/i1+1
InChI Key PYMYPHUHKUWMLA-IQGOOSNCSA-N

D-Lyxose-[1-13C], a renowned stable isotope-labeled sugar, finds widespread utility in diverse biochemical and industrial realms. Here are the key applications of D-Lyxose-[1-13C]:

Metabolic Flux Analysis: Central to metabolic flux analysis is the utilization of D-Lyxose-[1-13C] for probing carbohydrate metabolism pathways. By tracking the assimilation of the 13C isotope into metabolic intermediates, researchers unveil the dynamics of metabolic reactions. This insight not only sheds light on disease metabolism intricacies but also optimizes metabolic engineering practices in biotechnology landscapes.

Structural Biology Studies: Within the domain of structural biology, D-Lyxose-[1-13C] serves as an indispensable tool for unraveling the three-dimensional structures of carbohydrate-binding proteins and enzymes. The incorporation of the 13C isotope furnishes intricate NMR and X-ray crystallography data, crucial for deciphering the nuances of enzyme catalysis mechanisms and carbohydrate-protein interactions.

Biophysical Research: Esteemed in biophysical research, D-Lyxose-[1-13C] plays a pivotal role in labeling carbohydrates for spectroscopic examinations. The 13C label significantly boosts resolution and sensitivity in NMR spectroscopy, enabling meticulous exploration of carbohydrate dynamics and interactions. Such detailed analyses are paramount for dissecting conformational changes and molecular behaviors of carbohydrates across diverse environmental settings.

Pharmaceutical Development: In the realm of pharmaceutical research, D-Lyxose-[1-13C] emerges as a key player in elucidating drug-carbohydrate interactions and designing carbohydrate-based therapeutic agents. By tagging drugs with the 13C isotope, researchers can meticulously track their dissemination and metabolism within biological systems. This knowledge contributes to optimizing drug delivery strategies and enhancing therapeutic efficacy for a myriad of medical applications.

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