Fmoc-D-Methionine-[d3]

Fmoc-D-Methionine-[d3] stands out as an isotopically-labeled amino acid derivative with diverse applications in bioscience. Here are the key applications of Fmoc-D-Methionine-[d3]:

Peptide Synthesis: Playing a pivotal role in peptide and protein synthesis, Fmoc-D-Methionine-[d3] showcases its deuterium labeling prowess, aiding in the precise identification and quantification of these molecular entities through mass spectrometry. This labeled amino acid becomes instrumental in investigating peptide stability, folding patterns, and intricate interactions. Moreover, it offers invaluable insights into protein structure and function, unraveling the mysteries of cellular machinery.

Metabolic Research: Delving into metabolic pathways, Fmoc-D-Methionine-[d3] emerges as a beacon for analyzing sulfur amino acid metabolism. By integrating this labeled compound into biological systems, researchers gain the ability to track metabolic flux and turnover rates in both controlled in vitro setups and dynamic in vivo experiments. Such utilization proves critical in unraveling the complexities of metabolic disorders and formulating effective therapeutic strategies.

Pharmacokinetics: Powering pharmacokinetic studies, Fmoc-D-Methionine-[d3] aids in the comprehensive evaluation of methionine-containing drug absorption, distribution, metabolism, and excretion (ADME). The distinctive deuterium labeling imparts a unique signature, facilitating precise tracking of the compound’s journey within living systems. This application significantly contributes to drug development endeavors by furnishing detailed metabolic and pharmacokinetic profiles, paving the way for optimized pharmaceutical solutions.

Proteomics: Within the realm of proteomics, Fmoc-D-Methionine-[d3] assumes a crucial role as a standard or internal marker in mass spectrometric analyses. Its integration into proteins enhances the accuracy of quantifying and identifying protein modifications and intricate interactions. Such precision is paramount for conducting comprehensive proteome profiling and unearthing potential biomarkers in diverse disease states, advancing our understanding of complex biological processes.