CAS 944386-47-4 D-Tyrosine-[d4] - Isotope / BOC Sciences

General Information
Catalog: BLP-001645
CAS: 944386-47-4
Molecular Formula: C9H7D4NO3
Molecular Weight: 185.21

General Information

Catalog: BLP-001645

CAS: 944386-47-4

Molecular Formula: C9H7D4NO3

Molecular Weight: 185.21

Chemical Structure

Description	D-Tyrosine-[d4] is the labelled analogue of D-tyrosine. Tyrosine is a non-essential amino acid synthesized from phenylalanine. It is the precursor of some neurotransmitters.
Synonyms	D-4-Hydroxyphenyl-2,3,5,6-d4-alanine; D-Tyrosine-(phenyl-d4); (2R)-2-Amino-3-(4-hydroxyphenyl)propanoic Acid-d4; (R)-Tyrosine-d4; D-p-Tyrosine-d4; H-D-Tyr-OH-d4; D-Tyrosine-d4; p-Hydroxyphenyl-D-alanine-d4; H-D-Tyr-OH-d4
IUPAC Name	(2R)-2-amino-3-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)propanoic acid
Related CAS	556-02-5 (unlabelled)
Isomeric SMILES	[2H]C1=C(C(=C(C(=C1C[C@H](C(=O)O)N)[2H])[2H])O)[2H]
Canonical SMILES	C1=CC(=CC=C1CC(C(=O)O)N)O
InChI	InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m1/s1/i1D,2D,3D,4D
InChI Key	OUYCCCASQSFEME-SFSAVJDPSA-N
Purity	≥ 99% (CP); ≥ 98% atom D
Solubility	Slightly soluble in Aqueous Acid
Appearance	White Solid
Storage	−20 °C

D-Tyrosine-[d4], an isotopically labeled amino acid crucial for biochemical and pharmaceutical research, offers a myriad of applications. Here are the key applications:

Metabolic Research: Delving into amino acid metabolism pathways, D-Tyrosine-[d4] is a linchpin in metabolic tracing studies. By integrating the labeled tyrosine into biological systems, researchers can trace its metabolic destiny and quantify its integration into proteins and other metabolites. This exploration sheds light on metabolic disorders and the impacts of dietary supplements on amino acid metabolism, unraveling the intricate web of metabolic intricacies.

Mass Spectrometry Studies: As an internal standard in mass spectrometry, D-Tyrosine-[d4] plays a pivotal role in quantifying tyrosine levels in diverse biological samples like plasma, urine, and tissue extracts. With its unique isotopic signature, it bolsters the precision and accuracy of mass spectrometric analyses, a critical step in biomarker discovery and diagnostic test development, offering a clearer lens into biological complexities.

Pharmacokinetics: Unveiling the mysteries of drug absorption, distribution, metabolism, and excretion (ADME), D-Tyrosine-[d4] is a beacon in pharmacokinetic studies. By administering the labeled compound and monitoring its concentration dynamics, researchers glean insights into drug bioavailability and metabolic pathways. This knowledge is indispensable for refining dosage regimens and enhancing therapeutic efficacy, paving the way for optimized treatment outcomes.

Protein Synthesis Research: A catalyst for protein synthesis research, D-Tyrosine-[d4] seamlessly integrates into proteins during in vitro or in vivo synthesis, enabling profound insights into protein structure, function, and dynamics. Through analysis of labeled proteins using nuclear magnetic resonance (NMR) or other spectral techniques, scientists unlock intricate details about protein folding, stability, and interactions. This foundational understanding is pivotal in tackling protein-related diseases and crafting innovative proteins with tailored functionalities, pushing the boundaries of scientific exploration.