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D-mannose-[UL-d7]

General Information
Catalog: BLP-007044
Molecular Formula: C6H5D7O6
Molecular Weight: 187.20
Chemical Structure
D-mannose-[UL-d7]
Description D-Mannose-[UL-d7] is a labeled analog of D-Mannose. D-mannose is important in the glycosylation of molecules. It is involved in N and O glycosylation of bovine. It is also used for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A.
Synonyms D-[UL-2H7]mannose; D-[1,2,3,4,5,6,6'-2H7]mannose; D-mannose-1,2,3,4,5,6,6-d7; D-[UL-D7]mannose
IUPAC Name (3S,4R,5R,6R)-6-(hydroxymethyl-d2)tetrahydro-2H-pyran-2,3,4,5,6-d5-2,3,4,5-tetraol
Related CAS 3458-28-4 (unlabelled)
Solubility Soluble in Methanol, Water
Appearance White to Off-white Solid
Storage Store at -20°C

D-mannose-[UL-d7], a labeled variant of D-mannose, plays a pivotal role in diverse research and clinical settings for studying carbohydrate metabolism and cellular processes. Here are the key applications of D-mannose-[UL-d7]:

Metabolic Tracing: In metabolic investigations, D-mannose-[UL-d7] serves as a potent tool for tracing the journey of mannose within cellular metabolism. By integrating the labeled mannose into metabolic pathways, researchers can meticulously monitor its conversion into various sugars and polysaccharides. This approach aids in unraveling the intricate dynamics of mannose utilization and sheds light on its pivotal role in cellular physiology.

Glycosylation Studies: Delving into the realm of protein glycosylation processes, D-mannose-[UL-d7] emerges as a valuable asset. Protein glycosylation involves the addition of mannose residues to proteins during post-translational modification. Through the utilization of labeled mannose, scientists can delve into the dynamic process of glycosylation, pinpoint specific mannose-containing glycoproteins, and unravel the nuances of protein function. This knowledge is instrumental in deciphering disease mechanisms linked to glycosylation disorders.

Nutritional Studies: In the realm of nutritional exploration, D-mannose-[UL-d7] emerges as a key player in investigating the absorption, distribution, and excretion of mannose in both human and animal models. Through the administration of labeled mannose, researchers embark on a journey to track its trajectory through the body, exploring its impact on health and disease. This research contributes significantly to the formulation of dietary guidelines and the development of therapeutic interventions, integrating mannose supplementation and enhancing our understanding of the intricate interplay between nutrition and physiological well-being.

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