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Demecolcine-[d3]

General Information
Catalog: BLP-012844
CAS: 1217668-72-8
Molecular Formula: C21H22D3NO5
Molecular Weight: 374.45
Chemical Structure
Demecolcine-[d3]
Description Demecolcine-[d3] is the labelled analogue of Demecolcine. Demecolcine is an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin. It also induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Synonyms Demecolcine D3; (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one-d3; Deacetylmethylcolchicine-d3; Colchamin-d3; NSC 3096-d3; Omain-d3; Omaine-d3; N-Desacetyl-N-methylcolchicine-d3; Colcemid-d3
IUPAC Name (7S)-1,2,3,10-tetramethoxy-7-(trideuteriomethylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
Related CAS 477-30-5 (unlabelled)
Canonical SMILES CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
InChI InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1/i1D3
InChI Key NNJPGOLRFBJNIW-VSLDJYOXSA-N
Melting Point 73-75°C
Purity >95%
Solubility Soluble in Dichloromethane, DMSO, Methanol
Appearance Faintly Yellow Crystalline Powder
Storage Store at -20°C under inert atmosphere

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