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Demecolcine-[d6]

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General Information
Catalog: BLP-012845
CAS: 1217602-04-4
Molecular Formula: C21H19D6NO5
Molecular Weight: 377.46

Chemical Structure

Description	Demecolcine-[d6] is the labelled analogue of Demecolcine. Demecolcine is an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin. It also induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Synonyms	Demecolcine D6; (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one-d6; Deacetylmethylcolchicine-d6; Colchamin-d6; NSC 3096-d6; Omain-d6; Omaine-d6; N-Desacetyl-N-methylcolchicine-d6; Colcemid-d6
IUPAC Name	(7S)-1,2,3-trimethoxy-10-(trideuteriomethoxy)-7-(trideuteriomethylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
Related CAS	477-30-5 (unlabelled)
Canonical SMILES	CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
InChI	InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1/i1D3,2D3
InChI Key	NNJPGOLRFBJNIW-AHQJRMJXSA-N
Melting Point	73-75°C
Purity	>95%
Solubility	Soluble in Dichloromethane, DMSO, Methanol
Appearance	Faintly Yellow Crystalline Powder
Storage	Store at -20°C under inert atmosphere