Name: N-Desmethyl Imatinib-[d4]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-013029

Molecular Formula: C28H25D4N7O

Molecular Weight: 483.60

Chemical Structure

Description	N-Desmethyl Imatinib-[d4] is the labelled analogue of N-Desmethyl Imatinib, which is a metabolite of Imatinib.
Synonyms	Desmethyl imatinib D4; N-Desmethyl Imatinib-d4; N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide-d4; N-Desmethyl Gleevec-d4; Norimatinib-d4; Imatinib EP Impurity C-d4
IUPAC Name	2,3,5,6-tetradeuterio-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-(piperazin-1-ylmethyl)benzamide
Related CAS	404844-02-6 (unlabelled)
Canonical SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCNCC3)NC4=NC=CC(=N4)C5=CN=CC=C5
InChI	InChI=1S/C28H29N7O/c1-20-4-9-24(17-26(20)34-28-31-12-10-25(33-28)23-3-2-11-30-18-23)32-27(36)22-7-5-21(6-8-22)19-35-15-13-29-14-16-35/h2-12,17-18,29H,13-16,19H2,1H3,(H,32,36)(H,31,33,34)/i5D,6D,7D,8D
InChI Key	BQQYXPHRXIZMDM-KDWZCNHSSA-N
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance	Light Yellow Solid
Storage	Store at -20°C

N-Desmethyl Imatinib-[d4], a metabolite of Imatinib, plays a pivotal role in pharmacokinetic and pharmacodynamic research. Here are the key applications of N-Desmethyl Imatinib-[d4]:

Pharmacokinetic Studies: Researchers utilize N-Desmethyl Imatinib-[d4] to scrutinize the absorption, distribution, metabolism, and excretion (ADME) of Imatinib. By tracking this labeled compound, scientists delve into the intricate metabolic pathways of the drug and pinpoint critical metabolites. This comprehensive analysis sheds light on the drug’s behavior within the body, aiding in the optimization of dosing regimens for enhanced therapeutic efficacy.

Drug-Drug Interaction Studies: Navigating the realm of drug interactions, N-Desmethyl Imatinib-[d4] is instrumental in exploring potential interplays between Imatinib and other medications. Monitoring the levels of this labeled metabolite allows scientists to discern the impact of co-administered drugs on Imatinib metabolism. Such studies are imperative for safeguarding patient well-being and averting adverse effects in clinical scenarios.

Quantitative Analysis: Serving as an internal standard for quantitative liquid chromatography-mass spectrometry (LC-MS) analysis, N-Desmethyl Imatinib-[d4] facilitates precise measurement of Imatinib and its metabolites in biological samples. The presence of the labeled compound ensures accurate and reproducible quantification of drug concentrations, essential for therapeutic drug monitoring and achieving optimal clinical outcomes with confidence.

Clinical Research: Embracing the realm of clinical investigation, N-Desmethyl Imatinib-[d4] is leveraged to probe the pharmacodynamics of Imatinib across diverse patient populations. By exploring how different cohorts metabolize the drug, researchers tailor treatments for specific demographics, such as individuals with genetic variations impacting drug metabolism. This individualized approach fosters the delivery of personalized and efficacious medical interventions, advancing the frontier of precision medicine.